There will be “significant delays” while six weeks of roadworks are carried out at the junction of Wigginton Road and Haxby Road.
The work will start on May 19 at the busy junction near York Hospital.
Under the plans, temporary traffic lights will be put in place but a spokesman for City of York Council has warned people to expect “significant disruption” and consider taking a different route while the work is carried out.
The scheme, which is expected to cost about £200,000, aims to reduce bus journey times by up to 90 seconds in the area.
Plans include putting in new traffic signals, altering part of Haxby Road to make it straighter, changing the layout of the junction and making the pedestrian crossing islands bigger.
Updated technology will also be installed, which will send live congestion information to the council’s traffic control centre so officers can change the traffic lights at busy times of day.
The scheme will be funded by York’s Better Bus Area – with some of the cash coming from bus companies – and aims to make services more reliable and efficient.
Roadworks will be carried out in stages, from 9.30am to 4pm on weekdays and 8am to 3pm on weekends. Drivers are being advised to leave extra time for their journeys.
Pedestrian crossings will be provided and no bus route diversions or closures are expected while the work is carried out. Cyclists are advised to take extra care because some bicycle lanes may be closed during the roadworks.
As part of the project, advanced stop lines and a feeder lane will be created at the junction with Haxby Road and Clarence Street.
Roundabout plan scrapped
Plans for the Fountayne Street mini-roundabout to be removed were scrapped after residents who took part in a consultation on the plans said this would make traffic worse.
The council has apologised for any disruption caused by the roadworks and said that people who live or work in the area should speak to staff on site if they have any problems.
Access to businesses and homes will be maintained at all times while the work takes place.
The project is expected to be finished by June 28.